Prerequisites: high school algebra or the instructor's permission. Recommended Preparation: high school physics and chemistry.

Not for credit toward the bachelor's degree. Given on a Pass/Fail basis only. This course is preparation for Chemistry F1403 or the equivalent, as well as for other science courses. It is intended for students who have not attended school for sometime or who do not have a firm grasp of high school chemistry. Topics include atomic and nuclear structure, nomenclature, chemical bonding and its relation to molecular structure, chemical reactions, stoichiometry, periodic properties of elements, equilibria, gas laws, acids and bases, and kinetics.

Recitation Section Required.

Prerequisites: for C1403: concurrent registration in MATH V1101; for C1404: CHEM C1403 or W1403.

Only students with scheduling conflicts need report to the Chemistry Department (340 Havemeyer) during registration. Preparation equivalent to one year of high school chemistry is assumed and concurrent registration in Calculus I. Students lacking such preparation should plan independent study of chemistry over the summer or take CHEM F0001 before taking C1403. Topics include stoichiometry, states of matter, chemical equilibria, acids and bases, chemical thermodynamics, nuclear properties, electronic structures of atoms, periodic properties, chemical bonding, molecular geometry, introduction to organic and biological chemistry, solid state and materials science, polymer science and macromolecular structures, chemical kinetics, coordination chemistry, and electrochemistry. Although C1403 and C1404 are separate courses, students are expected to take both terms sequentially. the order of presentation of topics may differ from the order presented here, and from year to year.

Recitation Section Required.

Prerequisites: for C1403: concurrent registration in MATH V1101; for C1404: CHEM C1403 or W1403.

Topics include kinetic theory of gases, solutions, equilibria, oxidation-reduction, reactions, thermodynamics, chemical kinetics, the electronic structure of atoms, chemical bonding and its relationship to the geometries of molecules, periodic properties of the elements, transition metal complexes, and an introduction to organic chemistry and biochemistry.

Recitation Section Required.

Corequisites: CHEM C1403 or W1403.

Laboratory Fee: $140. An introduction to basic techniques of modern experimental chemistry, including quantitative procedures and chemical analysis.

Corequisites: CHEM C1403 or W1403.

Laboratory Fee: $140. An introduction to basic techniques of modern experimental chemistry, including quantitative procedures and chemical analysis.

Prerequisites: A grade of "B" or better in CHEM C1403 or W1403 or acceptable performance on the Department placement exam.
Corequisites: Calculus II.

Topics include: Gases (Kinetic Theory of Gases); Binary Collision Model for Chemical Reactions; Chemical Kinetics; Acid-base Equilibria; Thermochemistry (Thermodynamics I); Thermodynamics II Spontaneous Processes; Chemical Bonding in Polyatomic Molecules.

Recitation Section Required.

Prerequisites: CHEM C1604 or C3045.

Laboratory Fee: $140. An introduction to basic techniques and practices of modern experimental chemistry, including qualitative procedures and chemical analysis. This course differs from CHEM C1500 in its emphasis on instrumentation and methods.

Prerequisites: A grade of 5 on the Chemistry Advanced Placement exam and an acceptable grade on the Department placement exam.

Not open to students who have taken other courses in college-level chemistry. Premedical students may take CHEM C3045, C3046, and C3545 to meet the minimum requirements for admission to medical school. This course covers the same material as CHEM C3443-C3444, but is intended for students who have learned the principles of general chemistry in high school. The level of instruction is appropriate for those who have not had a college course in general chemistry. Students enrolled in CHEM C3045-C3046 are expected to enroll concurrently in CHEM C2507.

Recitation Section Required.

Prerequisites: CHEM C1403 and C1404, or C1604, or C3045 and C3046; PHYS V1201-V1202 is acceptable, PHYS C1401-C1402 is recommended, or the equivalent; and MATH V1101-V1102 or V1207-V1208. Recommended corequisite: CHEM C3085-C3086.

Elementary but comprehensive treatment of the fundamental laws governing the behavior of individual atoms and molecules and collections of them. C3079: The thermodynamics of chemical systems at equilibrium and the chemical kinetics of nonequilibrium systems. C3080: The quantum mechanics of atoms and molecules, the quantum statistical mechanics of chemical systems, and the connection of statistical mechanics to thermodynamics.

Recitation Section Required.

Prerequisites: CHEM C3085 is prerequisite for C3086.
Corequisites: CHEM C3079 for CHEM C3085 and C3080 for C3080.

Laboratory Fee: $125 per term. Techniques of experimental physical chemistry and instrumental analysis, including infrared and ultraviolet spectrophotometry, magnetic resonance, electroanalytical methods, calorimetry, reaction kinetics, hydrodynamic methods, and applications of digital computers to the analysis of experimental data.

Prerequisites: CHEM C1404 or F1404 or C1604, and C1500 or F1500.

The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination.

Recitation Section Required.

Prerequisites: CHEM C1404 or F1404 or C1604, and C1500 or F1500.

The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination.

Recitation Section Required.

Prerequisites: ENVB W2001 or BIOL C2005 and one year of organic chemistry.

Lecture and recitation. Students wishing to cover the full range of modern biochemistry should take both BIOC C3501 and C3512. Protein structure, protein folding, enzyme kinetics, allostery, membrane transport, biological membranes, and protein targeting. Chemistry and metabolism of amino acids, carbohydrates, lipids, purines, and pyrimidines.

Recitation Section Required.

Prerequisites: CHEM C1500 or F1500.
Corequisites: CHEM C3443 or F3343.

Laboratory Fee: $125. Students planning to take a full year of laboratory should enroll in CHEM C3543 and C3546. Techniques of experimental organic chemistry, with emphasis on understanding fundamental principles underlying the experiments in methodology of solving laboratory problems involving organic molecules.

Prerequisites: CHEM C1500 or F1500.
Corequisites: CHEM C3443 or F3343.

Laboratory Fee: $125. Students planning to take a full year of laboratory should enroll in CHEM C3543 and C3546. Techniques of experimental organic chemistry, with emphasis on understanding fundamental principles underlying the experiments in methodology of solving laboratory problems involving organic molecules.

Prerequisites: CHEM C3045 and C3046 and C2507.

Laboratory Fee: $125. The course covers the same material as CHEM C3543, but is intended for those students who have taken Intensive Organic Chemistry for First-Year Students, CHEM C3045-C3046.

Prerequisites: Elementary organic chemistry. (Some background in inorganic and physical chemistry is helpful but not required.)

Main group and transition metal organometallic chemistry: bonding, structure, reactions, kinetics, and mechanisms.

Prerequisites: Elementary organic and physical chemistry.

The mechanisms of organic reactions, structure of organic molecules, and theories of reactivity. How reactive intermediates are recognized and mechanisms are deduced using kinetics, stereochemistry, isotopes, and physical measurements.

Prerequisites: Elementary physical chemistry.

Basic quantum mechanics: the Schrodinger equation and its interpretation, exact solutions in simple cases, methods or approximation, angular Mementum and electronic spin, and an introduction to atomic and molecular structure.

Prerequisites: Elementary physical chemistry.
Corequisites: CHEM G4221

Topics include the classical and quantum statistical mechanics of gases, liquids, and solids.

Prerequisites: One year of Biology, Chemistry and Physics. Courses taken at CU are recommended, but AP courses may be sufficient with permission from the instructors.

This course will present a quantitative description of the molecular networks that underlie the myriad phenotypes in living cells, from yeast to human. Topics covered include various high-throughput genomics technologies (DNA sequencing, mRNA expression profiling, ChIP, proteomics), mathematical models of transcriptional and post-transcriptional regulatory networks, quantitative genetics of gene expression, synthetic biology and the world of RNA structure, dynamics and function. These topics will be integrated with introductory lectures on molecular and structural biology, thermodynamics, statistics and machine learning. The course is intended for advanced undergraduates as well as beginning graduate students in Biology, Chemistry, Physics, Engineering and Computer Science. Taught by research scientists active in various areas of systems biology, the course is highly interdisciplinary and rooted in recent research.

Construction, analysis and strategies for the synthesis of complex natutal products.

Review of principles of the mechanisms of organic photochemical reactions.

Prerequisites: high school algebra or the instructor's permission. Recommended Preparation: high school physics and chemistry.

Not for credit toward the bachelor's degree. Given on a Pass/Fail basis only. This course is preparation for Chemistry F1403 or the equivalent, as well as for other science courses. It is intended for students who have not attended school for sometime or who do not have a firm grasp of high school chemistry. Topics include atomic and nuclear structure, nomenclature, chemical bonding and its relation to molecular structure, chemical reactions, stoichiometry, periodic properties of elements, equilibria, gas laws, acids and bases, and kinetics.

Recitation Section Required.

Prerequisites: for C1403: concurrent registration in MATH V1101; for C1404: CHEM C1403 or W1403.

Only students with scheduling conflicts need report to the Chemistry Department (340 Havemeyer) during registration. Preparation equivalent to one year of high school chemistry is assumed and concurrent registration in Calculus I. Students lacking such preparation should plan independent study of chemistry over the summer or take CHEM F0001 before taking C1403. Topics include stoichiometry, states of matter, chemical equilibria, acids and bases, chemical thermodynamics, nuclear properties, electronic structures of atoms, periodic properties, chemical bonding, molecular geometry, introduction to organic and biological chemistry, solid state and materials science, polymer science and macromolecular structures, chemical kinetics, coordination chemistry, and electrochemistry. Although C1403 and C1404 are separate courses, students are expected to take both terms sequentially. the order of presentation of topics may differ from the order presented here, and from year to year.

Recitation Section Required.

Prerequisites: for C1403: concurrent registration in MATH V1101; for C1404: CHEM C1403 or W1403.

Topics include kinetic theory of gases, solutions, equilibria, oxidation-reduction, reactions, thermodynamics, chemical kinetics, the electronic structure of atoms, chemical bonding and its relationship to the geometries of molecules, periodic properties of the elements, transition metal complexes, and an introduction to organic chemistry and biochemistry.

Recitation Section Required.

Corequisites: CHEM C1403 or W1403.

Laboratory Fee: $140. An introduction to basic techniques of modern experimental chemistry, including quantitative procedures and chemical analysis.

Corequisites: CHEM C1403 or W1403.

Laboratory Fee: $140. An introduction to basic techniques of modern experimental chemistry, including quantitative procedures and chemical analysis.

Prerequisites: CHEM C1403, C1604, or C3045 or the instructor's permission.

A one-hour weekly lecture, discussion, and critical analysis of topics that reflect problems in modern chemistry, with emphasis on current areas of active chemical research.

Prerequisites: CHEM C1604 or C3045.

Laboratory Fee: $140. An introduction to basic techniques and practices of modern experimental chemistry, including qualitative procedures and chemical analysis. This course differs from CHEM C1500 in its emphasis on instrumentation and methods.

Prerequisites: A grade of 5 on the Chemistry Advanced Placement exam and an acceptable grade on the Department placement exam.

Not open to students who have taken other courses in college-level chemistry. Premedical students may take CHEM C3045, C3046, and C3545 to meet the minimum requirements for admission to medical school. This course covers the same material as CHEM C3443-C3444, but is intended for students who have learned the principles of general chemistry in high school. The level of instruction is appropriate for those who have not had a college course in general chemistry. Students enrolled in CHEM C3045-C3046 are expected to enroll concurrently in CHEM C2507.

Recitation Section Required.

Prerequisites: CHEM C1403 and C1404, or C1604, or C3045 and C3046; PHYS V1201-V1202 is acceptable, PHYS C1401-C1402 is recommended, or the equivalent; and MATH V1101-V1102 or V1207-V1208. Recommended corequisite: CHEM C3085-C3086.

Elementary but comprehensive treatment of the fundamental laws governing the behavior of individual atoms and molecules and collections of them. C3079: The thermodynamics of chemical systems at equilibrium and the chemical kinetics of nonequilibrium systems. C3080: The quantum mechanics of atoms and molecules, the quantum statistical mechanics of chemical systems, and the connection of statistical mechanics to thermodynamics.

Recitation Section Required.

Prerequisites: CHEM C3085 is prerequisite for C3086.
Corequisites: CHEM C3079 for CHEM C3085 and C3080 for C3080.

Laboratory Fee: $125 per term. Techniques of experimental physical chemistry and instrumental analysis, including infrared and ultraviolet spectrophotometry, magnetic resonance, electroanalytical methods, calorimetry, reaction kinetics, hydrodynamic methods, and applications of digital computers to the analysis of experimental data.

Prerequisites: CHEM C1404 or F1404 or C1604, and C1500 or F1500.

The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination.

Recitation Section Required.

Prerequisites: CHEM C1404 or F1404 or C1604, and C1500 or F1500.

The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination.

Recitation Section Required.

Prerequisites: One year of biology and one year of organic chemistry. Recommended but not required: BIOC C3501.

Nucleic acid structure and enzymology. DNA replication, DNA repair, and transcription. RNA processing and translation. Biochemical approach to the study of gene expression and regulation with emphasis on the diseases caused when the basic processes are altered. Students may take BCHM G4026 in place of this course.

Recitation Section Required.

Prerequisites: CHEM C1500 or F1500.
Corequisites: CHEM C3443 or F3343.

Laboratory Fee: $125. Students planning to take a full year of laboratory should enroll in CHEM C3543 and C3546. Techniques of experimental organic chemistry, with emphasis on understanding fundamental principles underlying the experiments in methodology of solving laboratory problems involving organic molecules.

Prerequisites: CHEM C1500 or F1500.
Corequisites: CHEM C3443 or F3343.

Laboratory Fee: $125. Students planning to take a full year of laboratory should enroll in CHEM C3543 and C3546. Techniques of experimental organic chemistry, with emphasis on understanding fundamental principles underlying the experiments in methodology of solving laboratory problems involving organic molecules.

Prerequisites: CHEM C3543 or F3543 or C3545.
Corequisites: CHEM C3444 or F3444.

Laboratory Fee: $125. A project laboratory with emphasis on complex synthesis and advanced techniques including qualitative organic analysis and instrumentation.

Prerequisites: Elementary organic chemistry.

Introduction to theory and practice of NMR spectroscopy. Instrumental aspects, basic NMR theory, NOE, and a survey of 2D methods are covered.

Prerequisites: Elementary physical and organic chemistry.

Recommended preparation: elementary biochemistry. Tactics and techniques for the study of large molecules of biological importance, analysis of the conformation of proteins and nucleic acids; hydrodynamic, scattering, and spectroscopic techniques for examining macromolecular structure.

Prerequisites: Elementary organic chemistry.

Recommended preparation: advanced organic chemistry. Various topics in bioactive molecules in the field centered on natural-products chemistry, metabolic transformations, and enzyme mechanisms. Biosysnthesis of natural products and some other bioorganic topics.

Prerequisites: One year of Biology and one year of Chemistry (AP in High School and/or at Columbia) or permission from the instructor.

A quantitative description of the molecular networks that underlie the myriad phenotypes in living cells. Topics covered include various high-throughput technologies (genome sequencing, DNA microarrays, proteomics and phenotypic drug screening), transcriptional and posttranscriptional regulatory networks, synthetic biology and neural networks. These will be integrated with introductory lectures on molecular and structural biology, thermodynamics, statistics and maching learning.

Prerequisites: Chemistry G4221 and G4230

Phase transitions and critical phenomena; renormalization group methods; classical theory of fluids.

Prerequisites: Chemistry G4221 or the equivalent.

Principles of the interaction of molecules with radiation. Applications of spectroscopy to elucidate molecular structure and bonding.

The use of multinuclear NMR spectroscopy in the determination of the structures of inorganic molecules and the use of dynamic NMR spectroscopy (variable temperature NMR and magnetization transfer techniques) to provide information concerned with reaction mechanisms.

Prerequisites: CHEM G8148.

Construction, analysis, and strategies for the synthesis of complex natural products.

Recent advances in the development of homogeneous catalysis for selective organic synthesis. Emphasis on both mechanistic and synthetic aspects.

Prerequisites: G4147 or permission from the instructor.

Intermolecular interactions are at the structure-reactivity and structure-function relations of many issues in material sciences and biological chemistry. This course will describe the fundamental concepts and methodologies of the field and review its development over the past several decades. Emphasis will be placed on guest-host systems which can be developed based on the paradigm of the chemistry of enzymes.