Prerequisites: ELEN E3801 or BIOL W3004

Biophysics of computation, the Hodgkin-Huxley neuron, modeling and analysis of ion channels, basic dendritic integration. Integrate-and-fire and other spiking neuron models, stimulus representation and the neural code, time encoding and stimulus recovery, information representation with time encoding machines, fast algorithms for stimulus recovery, elements of spike processing and neural computation. Modeling synapses and synaptic transmission, synaptic plasticity and learning algorithms. Projects in Matlab.

Prerequisites: None. Introduction to the information system paradigm of molecular biology. Representation, organization, structure, function and manipulation of the biomolecular sequence of nucleic acids and proteins. The role of enzymes and gene regulatory elements in natural biological functions as well as in biotechnology and genetic engineering. Recombination and other macromolecular processes viewed as mathematical operations with simulation and visualization using simple computer programming.